Lady Anne Mowbray was the only child of John Mowbray KG, 4th. Duke of Norfolk. Born 17 December 1472 at Framlingham Castle, Suffolk, she was only three years of age when her father died, leaving her heiress to the vast Mowbray estates. These were looked upon by Edward IV as ripe for amalgamation with his Yorkist possessions and on the 15 Jan 1477 the five year old Lady Anne was married in St.Stephen's Church, Westminster to the king's younger son Prince Richard, Duke of York. Richard's elder brother Edward had been born in 1470 so Richard was little, if anything, older than Anne.

The marriage was not to be consummated. Lady Anne contracted the plague and died in 19 November 1481 a month before her ninth birthday and two years before the disappearance of the Princes.

Anne was buried in the Chapel of Erasmus in Westminster Abbey, but when it was demolished about 1502, her body was transferred to a convent in the Minories, near Tower Hill. The convent disappeared over the years, but Anne's coffin was discovered on the site in 1964. On 31 May 1965 she was re-buried in Westminster Abbey near a sarcophagus thought to contain the bones of her husband and his brother.

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